Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Tocris Bioscience™ Sarpogrelate hydrochloride
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Selective 5-HT2A antagonist
| Inhibitors | Sarpogrelate hydrochloride |
|---|---|
| Product Type | Sarpogrelate hydrochloride |
| Molecular Weight (g/mol) | 465.97 |
| Purity | >99% |
Tocris Bioscience™ Lomitapide mesylate
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Potent microsomal triglyceride transfer protein (MTP) inhibitor
| Target | Lipid Metabolism Inhibitors |
|---|---|
| CAS | 2059395-52-5 |
| Purity | 0.98 |
| Chemical Name or Material | N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4 '-(trifluoromethyl)[1,1 '-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9 H-fluorene-9-carboxamide methanesulfonate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C39H37F6N3O2.CH3SO3H |
Tocris Bioscience™ BSJ-4-116
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Selective CDK12 PROTAC™ Degrader
Tocris Bioscience™ Verdinexor
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Selective exportin-1 (XPO1/CRM1) inhibitor
| Target | Antiviral Compounds |
|---|---|
| CAS | 1392136-43-4 |
| Purity | 0.98 |
| Chemical Name or Material | (2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H12F6N6O |
Tocris Bioscience™ TC LPA5 4
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CAS: 1393814-38-4 Molecular Formula: C23H23ClN2O3
| CAS | 1393814-38-4 |
|---|---|
| Molecular Formula | C23H23ClN2O3 |
Tocris Bioscience™ ESI 1
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Selective HDAC3 inhibitor; also myelination inducer
| Target | Class I Histone Deacetylases Inhibitors |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H17N5O.2HCl |
Tocris Bioscience™ A 784168
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CAS: 824982-41-4 Molecular Formula: C19H15F6N3O3S
| CAS | 824982-41-4 |
|---|---|
| Molecular Formula | C19H15F6N3O3S |
Tocris Bioscience™ VER 155008
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CAS: 1134156-31-2 Molecular Formula: C25H23Cl2N7O4
| CAS | 1134156-31-2 |
|---|---|
| Molecular Formula | C25H23Cl2N7O4 |
Tocris Bioscience™ ASP 2535
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Potent and selective GlyT1 inhibitor
Tocris Bioscience™ AZ PFKFB3 67, >98%
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CAS: 1704741-11-6 Molecular Formula: C26H25N5O3
| CAS | 1704741-11-6 |
|---|---|
| Molecular Formula | C26H25N5O3 |
Tocris Bioscience™ c-Di-AMP sodium salt
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Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Tocris Bioscience™ ABT 199
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Selective, high affinity Bcl-2 inhibitor; orally bioavailable
| Target | Bcl-2 Family Inhibitors |
|---|---|
| CAS | 1257044-40-8 |
| Product Type | Inhibitor |
| Purity | 98% |
| Chemical Name or Material | 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide |
| Recommended Storage | Store at -20°C |
| Synonym | GDC-0199 |
| Molecular Formula | C45H50ClN7O7S |
| Formula Weight | 868.45 |
Tocris Bioscience™ Pomalidomide 4'-PEG1-acid
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Cereblon ligand with PEG linker and terminal acid for onward chemistry
Tocris Bioscience™ MS 275
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HDAC (Class I) inhibitor
| CAS | 209783-80-2 |
|---|---|
| Chemical Name or Material | (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C21H20N4O3 |
| Formula Weight | Observed MW: 376.41 |
| Assay Percent Range | >99% |
Tocris Bioscience™ VX 745
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CAS: 209410-46-8 Molecular Formula: C19H9Cl2F2N3OS
| CAS | 209410-46-8 |
|---|---|
| Molecular Formula | C19H9Cl2F2N3OS |